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Melatonin enhances antioxidative enzyme gene expression (CAT, GPx, SOD), prevents their UVR-induced depletion, and protects against the formation of DNA damage (8-hydroxy-2'-deoxyguanosine) in ex vivo human skin

Gpx4 expression was decreased in Mac-CF AM cells at Day 3 and 5 post-inoculation ( Supplementary Figure 3E )

Fluorescence microscopy studies have documented rapid cellular accumulation, with detectable intracellular concentrations within 30 minutes of external application at physiological concentrations

SL and KAR have been reported to be recognized by the homologous proteins D14 (DWARF14) 14,15,16,17 and HTL (HYPOSENSITIVE TO LIGHT