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It has to be kept in mind, however, that cystine can also be transported by EAATs (Hayes et al., 2005)

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After discovering that NO-affecting 15-hydroperoxy-eicosa-tetra-enoyl-phosphatidylethanolamine produced by 15-lipoxygenase (15-LOX) modulate the ferroptosis endurance in M1 macrophages [60], researchers further found that ROS like O2 and NO uses the same entry pores and channels connecting to 15-LOX-2 catalytic site for competition [61]

This suggests that the different linker sequences and crystal lattice packing do not significantly perturb the structures of the target proteins, further validating the linker design strategy

Other studies have demonstrated that MPTP activates the apoptotic cascade by inducing Bax and caspase-3, resulting in caspase-dependent programmed cell death [98, 99]