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Notably, mPTP opening represents a critical decision point in cell fate: transient, low-conductance openings serve physiological roles in Ca 2+ homeostasis, whereas sustained, high-conductance opening exceeding the point of no return inevitably leads to mitochondrial swelling, outer membrane rupture, and cell death via apoptosis or necrosis (94)

doi: 10.1111/j.1528-1167.2010.02956.x 63

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Estrogen (diethylstilbestrol) was used for medical castration as an alternative to orchiectomy to suppress testosterone levels

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