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For example, the interaction between ApoE and TREM2, another major risk factor for sporadic AD, has been reported to facilitate the uptake of A by microglia, and AD-linked mutations in TREM2 impair the binding affinity of TREM2 for ApoE leading to A accumulation in the brain (Yeh et al., 2016)

Phase II study of troxacitabine, a novel dioxolane nucleoside analog, in patients with refractory leukemia

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Anyone considering this treatment should discuss the pros and cons with their doctor

Formation of ROS via photo-oxidation affects the rods more severely since these cells detect dim light to provide night vision and are more vulnerable to damage induced by daylight 23