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For hypoxic experiments, cells were exposed to normoxia (21% O 2 ) and moderate hypoxia (0.2% O 2 ) for 48 h using a modular atmosphere-controlled system Whitley H85 hypoxystation- Don Whitley Scientific

PINK1 phosphorylates MIC60/mitofilin to control structural plasticity of mitochondrial crista junctions

An omnivorous diet allows for the B12 intake through animal products (with a bioavailability ranging from 24% to 36% in eggs, up to 65% in lean meat) (Doets et al., 2013), while vitamin B12 is scarce or absent in diets including little or no animal products

First, its interplay with lipid metabolism: surplus pyruvate generated through glycolysis is converted to acetyl-CoA, which can enter lipid biosynthetic pathways and promote the synthesis of fatty acids, particularly PUFAs