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Vascular endothelium Many studies have confirmed that radiation exposure causes irreversible damage to vascular endothelial cells 37

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According to clinical research parenteral administration (intramuscular or intravenous) is preferred over other drug administration routes in case of emergency situations as it provides first-pass metabolism avoidance, reliable therapeutic concentrations and better bioavailability of dosage (2) It can also be used in situations when oral route is not feasible

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Furthermore, neutralizing antibodies specific to IL-6 and IL-10 showed no effect on the intracellular growth inhibitory effect of PAF C-16 (Supplementary Figures 1, 2)