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Specifically, elevated ROS levels lead to cell phenotype remodeling, whereby hepatocytes undergo transformation to more invasive or tumorigenic phenotypes, supported by metabolic reprogramming and epigenetic changes

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Additionally, the investigators were unaware of group allocation during the analysis of experimental data

with 2, 3, 4, or 5 g/kg EtOH as a 20% (w/v) solution in 0.9% NaCl warmed to 37C

In RAW 264.7 cells and colon epithelial cells, HT-29 is found that caffeic acid acts as an anti-inflammatory modulator by suppressing the production of nitric oxide (NO), IL-1, IL-6, IL-8, and TNF-, suggesting their potential therapeutic in IBD [365]