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Specifically, PBMC transfection with hm 5 C-modified LNP-saRNA resulted in 8.5- and 3-fold lower expression of these cytokines, respectively, compared to unmodified RNA [261]

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Others utilized a localized rectal irradiation mouse model, which simulates pelvic radiation therapy provided in the clinic, finding a disruption in the colonic microbiome accompanied by an increase in TNF, IL-1, and IL-6 in the irradiated mice

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Interestingly, HR in yeast was shown to aid DPC processing following chronic, low dose exposure to formaldehyde while not contributing significantly to the repair of acute, high dose treatment (97)

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Milanski M, Degasperi G, Coope A, Morari J, Denis R, Cintra DE, Velloso LA (2009) Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity

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