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In another randomized controlled trial of 79 women with episodic migraines without aura, supplementation with 300 mg lipoic acid twice daily was found to significantly reduce mood symptoms of depression, anxiety, and stress (assessed by DASS-21, a standardized scoring system) compared with placebo (Rezaei Kelishadi 2021)

A course of 3 mg of melatonin per day for 4 months had been given orally to the 48 patients and a placebo had been provided to the rest of the members (47 patients)

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We probably would have been in similar circles

Some biomarkers are usually increased relatively quickly after pollution treatment like: pH, lactic acid content , sebum production and secretion, advanced glycation end products (AGE), malondialdehyde (MDA) and squalene monohydroperoxide (SQOOH) (marker for lipid peroxidation), protein oxidation, cellular oxidative stress levels (radicals), Interleukin-1a (IL), IL-6