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In contrast to exogenous antioxidants, high levels of endogenous antioxidants do not appear to contribute to oxidative stress

10.1104/pp.105.066803 99 LuoM.LiangX

Carvalho RD, Breyner N, Menezes-Garcia Z, Rodrigues NM, Lemos L, Maioli TU, et al

However, in diabetic wounds, the transition from M1 to M2 is disrupted, leading to the accumulation of M1 macrophages, which produce ROS and sustain long-term inflammation

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