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Third, combination of the polyR with the sequence from diseasespecific pathogenic protein/peptide provided great feasibility and flexibility in applying this design across different misfolded aggregateassociated diseases

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PDKs and tumorimmune metabolic crosstalk Metabolic reprogramming plays a critical role in determining therapeutic response by modulating the cytotoxic functions of tumor-associated immune cells through altered immune metabolism and nutrient availability [168]

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