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Furthermore, given the aforementioned purported mechanisms for the improving effects of L-carnitine/synbiotics on weight or metabolic parameters, it could be conceived that concomitant supplementation of L-carnitine and synbiotics may confer more pronounced impacts on these indicators, potentially through simultaneous modulation of energy homeostasis (8, 30), increasing fatty acid oxidation (8, 30), reducing adipogenesis or stimulating adipocyte lipolysis (21, 30), alleviating insulin resistance and glucose homeostasis (10, 31, 33), or attenuating systemic inflammation (56, 57), in a complementary or synergistic manner probably mediated through concurrent targeting of metabolic/inflammatory signaling pathways including CPT-Ia (20, 21), PDHC (8, 19), PPAR- (21, 31, 37), AMPK (30, 37), or NF-B (31, 34)

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A 2016 systematic review and meta-analysis published in Obesity Reviews (Pooyandjoo et al.), which pooled data from nine randomised controlled trials, found that L-carnitine supplementation was associated with a statistically significant but modest reduction in body weight compared to placebo approximately 1.3 kg on average