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The combination of estrogen and GLP-1 was found to improve body weight and glycemic control in rodent models with the metabolic syndrome (158)

Tirzepatide aids in weight reduction by signaling fullness to reduce food intake and slowing gastric emptying, which collectively contribute to weight loss

The improved T cell response in the dblGATA-1 mice was also reflected at the metabolic level, with a notable upregulation of a glycolytic gene signature especially in the Th1 cluster ( Figure 6G )

Rotenone-induced PC12 cell toxicity is caused by oxidative stress resulting from altered dopamine metabolism

The study also emphasized the critical role of acetate-producing gut flora and their metabolites in mediating the metabolic and inflammatory balance [209]