Nakamura, T., Arii, S., Monden, Z., Furutani, M., Takeda, Y., Imamura, M., Tominaga, M
Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: a potential theranostic agent
- different GST isoenzymes exist in plants Often GSTs are the basis of herbicide selectivity: - crop plants (maize): high GST activity - competing weeds: low GST activity Herbicide detoxification by GSTs Triazines: atrazine, simazine Chloroacetanilides: acetochlor, alachlor, metolachlor Thiocarbamates: EPTC Nitrodiphenylethers: acifluorfen, fluorodifen Sulfonylureas: chlorimuron ethyl Others: chlorfenprop-methyl, metribuzin Transgenic tobacco Transformation of tobacco with a maize gene encoding the GST27 isoenzyme conferred tolerance to chloroacetanilide herbicides (Jepson et al., 1997) Herbicide safeners (antidotes) Wide range of synthetic compounds They increase the herbicide tolerance in crop plants (usually in cereals) Mode of action: Selective induction of GST isoenzymes participating in herbicide detoxification Other toxic GST substrates 1,2-dichloro-4-nitrobenzene 1-chloro-2,4-dinitrobenzene 4-nitropyridine-N-oxide p-nitrophenethyl-bromide p-nitrobenzyl chloride bromosulfophthalein Classical definition of GSTs: GSTs catalyze the conjugation of glutathione to a wide range of toxic and hydrophobic compounds large isoenzyme family predominantly cytosolic in maize: 1-2% of all soluble proteins endogenous, physiological substrates
conducted a study that demonstrated decreased protein levels of mitochondrial complexes I, III, and V in T21 brain tissue
Antioxidants 10 , 128 (2021)
