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A critical relationship exists between -syn aggregation and ferroptosis

Presently a considerable number of PPs in the form of antioxidant supplements, cosmetic and food additive products, sanitary agents, antibacterial products, and pain relievers are available in global markets for non-clinical applications (338)

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doi: 10.1016/j.bbamcr.2020.118867 56 CookC

Under non-stress conditions, Nrf2 remains tethered to Keap1, which promotes its ubiquitination and degradation, keeping Nrf2 activity low 65,66