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Moreover, Hu et al

-- The alkylating chemotherapeutic temozolomide induces metabolic stress in IDH1 -mutant cancers and potentiates NAD+ depletion-mediated cytotoxicity

On the contrary, lactate, pyruvate, and cysteine enhanced intracellular survival/replication inside phagocytic cells such as macrophages (Kanojiya et al., 2022b)