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Instead of aiming at inhibition or modulation of the traditional targets of antibiotics, attempts are being made to identify pathways necessary for the microbes virulence (i.e., ability to cause a disease or damage) and the pathogenesis (how the infection develops to a disease) [71]

Hippo signaling pathway The Hippo signaling pathway regulator transcription regulator 1 (TAZ) regulates ferroptosis through epithelial membrane protein 1 (EMP1)-NOX4, which means that ferroptosis may be a therapeutic target for renal cell carcinoma and other TAZ-activated tumors [88]