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[12] Though studies in hamster kidney tumor models showed weak carcinogenicity, the carcinogenic potential of 16-OHE 2 in humans remains unknown

The ischemia-reperfusion injury (I/R injury) of Sirt5 knockout mouse heart is restored to normal levels by dimethyl malonate (a succinate dehydrogenase (SDH) inhibitor) pretreatment, which implies that the change of SDH activity is the leading cause of the damage

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