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Repletion of vitamin B12 may improve response in patients resistant to antidepressants (10) , and in older adults with major depression, long-term supplementation with a combination of B12, B6, and folic acid enhanced antidepressant treatment efficacy (40)

Regulatory Note Both MOTS-C and AOD9604 are sold in the UK strictly as research chemicals, not licensed medicines, and are not approved for human or animal consumption

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High altitude residents have inhabited the Andes for approximately 9,000 to 12,000 years, but people have lived in the Himalayan plateau for more than 50,000 years [ 11 , 12 ]