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In addition, we detected a significant increase in the intracellular level of MDA, a cytotoxic product produced by lipid peroxidation metabolism (Fig

Copper interacts with the key aggregation-prone proteins associated with ALS, including TAR DNA binding protein 43 (TDP-43), CuZn-SOD, and fused in sarcoma (FUS)

It remains unclear whether metabolic states primarily drive epigenetic changes, or whether epigenetic mechanisms are the dominant regulators influencing cellular metabolism

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