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While there have been studies to show that people with MTHFR gene variants are more likely to have babies with neural tube defects, most of those studies were done in countries where there isnt routine folic acid fortification

doi: 10.2337/dc19-0883 29 RosenstockJAllisonDBirkenfeldALBlicherTMDeenadayalanSJacobsenJBet al

Gottschalk C, Barthel J, Engelhardt G, Bauer J, Meyer K

Management approaches include increasing fiber intake gradually (too much fiber at once worsens bloating), drinking at least 64 ounces of water daily, taking magnesium citrate (400-600mg at bedtime), and increasing physical activity

Thiamine deficiency may exacerbate oxidative stress and neuroinflammation, accelerate cerebrovascular dysfunction and cognitive impairment, and ultimately increase mortality risk among patients with SAD