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77 Increased excitatory neurotransmission, 78 enhanced non-auditory projections, 79 and changes in GABAergic transmission contribute to the excitatoryinhibitory imbalance

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The H3K79 histone methylation at promoters is implicated in leukemic transformation and progression

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Currently, Setmelanotide is being tested as a therapeutic option for rare genetic disorders of obesity such as POMC deficiency, heterozygous deficiency obesity, and POMC epigenetic disorders (30-32)