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Notably, STAT1 can be activated by a variety of ligands, which means that other cytokines may have similar effects to that of IFN in triggering ferroptosis

Understanding the physiological significance of such ability of metallated SOD1 WT to self-repair its disulfide bond in the presence of ubiquitous biological thiols, and how this ability is affected by fALS mutations, requires further investigation

The antibiotic-induced neuroprotective effects were abolished if regulatory T cells were depleted in the CCI mice, suggesting that gut microbiota influences the inflammatory responses and regulates pain hypersensitivity (Ding et al., 2021)

By maintaining a healthy gut barrier, glutamine indirectly supports the immune system by preventing the entry of pathogens and toxins that could trigger an immune overreaction