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J Alzheimers Dis 82(1):149157 Yu X, Zhang S, Zhao D, Zhang X, Xia C, Wang T, Zhang M, Liu T, Huang W, Wu B (2019) SIRT1 inhibits apoptosis in in vivo and in vitro models of spinal cord injury via microRNA-494

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In addition, since mitochondrial dysfunction leads to the activation of apoptosis, SIRT1 can directly regulate the apoptotic process by modulating acetylation of PGC-1 (Zhang et al., 2019)

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In vitro studies by Matalka et al

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