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In older adults, GlyNAC supplementation upregulated markers of mitochondrial biogenesis and energy metabolism, improved intercellular communication, as well as down-regulated of HOMA-IR, fasting insulin, and (pAMPK)/AMPK and thus indicating alterations of nutrient sensing

Weckman AM, McDonald CR, Baxter J-AB, Fawzi WW, Conroy AL, Kain KC (2019) Perspective: L-arginine and L-citrulline supplementation in pregnancy: a potential strategy to improve birth outcomes in low-resource settings