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The main enzymes involved in enzymatic reactions are uncoupled endothelial nitric oxide synthase (eNOS), NADPH oxidase (NOX), xanthine oxidase (XO), arachidonic acid (ARA), peroxidase, and metabolic enzymes such the cytochrome P450 system, cyclooxygenase, and lipoxygenase

In particular, there is a need for studies that examine the interactions between different interventions, such as the combined effects of exercise, diet, and pharmaceutical agents like metformin or rapamycin, to provide a more holistic understanding of how these factors work together to promote longevity

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Chen Z, Myers R, Wei T, Bind E, Kassim P, Wang G, Ji Y, Hong X, Caruso D, Bartell T, Gong Y, Strickland P, Navas-Acien A, Guallar E, Wang X (2014) Placental transfer and concentrations of cadmium, mercury, lead, and selenium in mothers, newborns, and young children

Mol Interv 7:31324 Mieyal JJ, Gallogly MM, Qanungo S, Sabens EA, Shelton MD (2008) Molecular mechanisms and clinical implications of reversible protein S -glutathionylation