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Tang et al., 2022)

Proteomics 75, 40744090

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Precursors that, when lacking, can affect the methylation process include: homocysteine choline methionine betaine Co-factors that affect methylation include: Zinc B2, B3, and B6 B12 Folate Enzyme polymorphism genes can also have a big role in how your methylation process works and include: COMPT MTHFR Homocysteine Low or high levels of homocysteine can affect your bodys methylation cycle significantly

Interestingly, all TARDBP family fibroblasts showed an increased reliance on glutamine, suggesting an anaplerotic use of Krebs cycle