TAM and vehicle chow TAM chow (500 mg TAM/kg diet, TD.130858, also contains 49.5 g/kg sucrose
Although normally cytosolic, HSPA12B can be released from endothelial cells upon damage, where it promotes the acquisition of a pro-regenerative phenotype in macrophages via TLR4 signaling (Doan et al., 2009) and the PI3KAKTmTOR pathway (Zhou et al., 2020)

All are critical for repairing the damage sustained in a concussion.[ix] Beneficial effects of the treatment include: Increased angiogenesis growth of new blood vessels Decreased edema (swelling) Increased lymphatic drainage Increased blood flow and cerebral oxygenation Decreased neuron excitotoxicity Anti-apoptosis reduced cell death Anti-inflammation Increased antioxidants Increased production of neurotrophins neuron growth factors Increased synaptogenesis a growth of new synapses Concussion treatment supplements and increasing BNDF Laser therapy has an additional benefit that is extremely valuable for treating concussion: It stimulates the production of brain-derived neurotrophic factor (BDNF).[x] Often called fertilizer for the brain, BDNF is crucial for repairing injured neurons and growing new ones, restoring communication among neurons, and reducing the long-term risk of neurodegeneration

Furthermore, UAE research suggests that Ipamorelin also supports better energy levels and tissue repair
Interestingly, when TBRF-specific antigens are utilized in Mexico, serologic studies point to ongoing circulation of TBRF spirochetes (Vazquez-Guerrero et al., 2019)