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However, there are multiple pathways that result in upregulation of COX-2 in brain neurons, including increased N-methyl-D-Aspartate (NMDA) receptor-dependent activity (230), cerebral ischemia, seizures, and diseases such as AD or PD (231)

This pathway is important for the biosynthesis of NADPH and pentoses

They may recover fully within three months

For example, a mutation was found in the tumor suppression gene PALB2 in a family with multiple lipomas suggestive of a diagnosis of FML (156)

It is a stress-inducible protein and protects the cells by regulating oxidative stress, endoplasmic reticulum stress, autophagy, metabolism, and inflammation