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(Wilson and Nicholson, 2017)

The nuclear factor kappa B (NF-B) signaling pathway is a key regulator of inflammatory and immune responses and plays a central role in this process [65]

Iglesias et al., 2014)

In the rodent studies reported to date it has generally been described as tolerated across the dose ranges examined, but comprehensive controlled human safety data do not exist, so conclusions about tolerability in people remain unconfirmed