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If tamariki with severe ulcerative colitis do not respond to treatment with TNF inhibitors, they may receive treatment with Ustekinumab

Wang L, Davis PB, Kaelber DC, Volkow ND, Xu R

A significant limitation of permeation enhancers is the potential for local mucosal irritation, impaired ciliary function, and epithelial disruption, particularly when surfactant-type enhancers are utilised at elevated concentrations or with prolonged exposure (Maher et al., 2019