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Notably, ODE stops cells from proliferating and urges them to die by activating p53 through ER/SP1

The system that removes these toxic reactive oxygen species includes a host of enzymes: Glutathione peroxidase (GPX): GPX detoxifies peroxides with glutathione acting as an electron donor in the reduction reaction, producing glutathione disulfide as an end product

Mol Brain 4:113 Zhang Y, Wang M, Chang W (2022) Iron dyshomeostasis and ferroptosis in Alzheimers disease: molecular mechanisms of cell death and novel therapeutic drugs and targets for AD

The GSH reactivity assay can be performed using single test compounds or as pools of 5* to accommodate higher throughput screening

Below are some practical considerations to help clinicians and savvy patients navigate dosing, stability, sourcing, and personalization