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For instance, preexisting neutralizing antibodies (NAbs) in the body can neutralize and precipitate AAV virus, activation of Toll-like receptors (TLRs) can trigger innate immunity, and AAV capsid proteins or nucleic acids can stimulate the production of antibodies against themselves

GSH is also consumed through glutathione S-transferase-catalyzed conjugation and reversible protein S-glutathionylation

Alizadeh, A., Dyck, S

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