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This suggests that the loss of positive charge in the CTD of the RSC and RS mutants increases the MgCl 2 concentration needed for DNA charge neutralization

Using an irradiation-induced osteosarcoma model, we found that Grm4 -/- mice were more susceptible to developing tumors compared with WT mice, and treatment with an agonist of mGluR4 efficiently suppressed osteosarcoma progression

i.e., liver blood flow decreased by 39% when pneumoperitoneum increased from 10 to 15 mmHg and liver ischemic injury occurred (Chen et al., 2017)

Pyroptosis releases inflammatory factors like interleukin-1 (IL-1) and interleukin-18 (IL-18), further exacerbating the inflammatory response [19]

& Kozai, K