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Moreover, despite their biomimetic architectural excellence, these systems inevitably constitute simplified approximations of the extraordinarily complex in vivo physiological milieu, potentially obscuring critical intercellular communication networks, systemic immunological responses, and multi-organ interaction paradigms that characterize authentic pathophysiological processes

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Concurrently, M1 macrophages possess the ability to activate NK T cells to secrete IFN-, thus accelerating the development of early-stage atherosclerosis (134)

The two peptides are widely studied together in tissue-repair, gastrointestinal and cardiovascular injury models