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Toxin Exposure: Chemicals, smoking, alcohol and pollution are said to lower the glutathione levels during the detoxification process

They include redox-sensitive molecular targets as signaling entities, such as Ras/Rac, Jun-N-terminal kinase (JNK), p38 mitogen-activated protein kinase (MAPK), the transcription factor NF-B, and protein tyrosine phosphatases

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Resolving these challenges will enable engineered bacteria to fulfill their potential as metabolite-directed tools for personalized cancer immunotherapy, unifying microbial engineering with immune metabolism