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Another mechanism involves activating death receptors of the tumor necrosis factor receptor (TNFR) superfamily which have high expression on target cells

Allard, V

Other ALDH2 approaches: Many investigational drugs showed promise in pre-clinical studies, including selective and reversible ALDH2 inhibitors (e.g., ANS-6637) and genetic targeting of liver ALDH2 messenger RNA to locally reduce hepatic ALDH2 expression (305, 306)