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This movement is caused by cellular swelling and a relative narrowing of extracellular gaps, which in turn generate slow-conducting waves of depolarization in multiple neurons and glial cells, resulting in the temporary inhibition of synaptic activity (Kowalska et al., 2021)

for instance, a recent phase II trial demonstrated that combining an ALOX15 inhibitor with low-dose corticosteroids significantly reduced the annualized exacerbation rate compared to corticosteroid monotherapy (161)

Autophagy Inhibition Enables Nrf2 to Exaggerate the Progression of Diabetic Cardiomyopathy in Mice

In addition, since dried blood is used, an adjustment in the sample preparation procedure is also necessary, since the dried sample of blood must be dissolved again before the analysis can be carried out

Additionally, these check-ups offer an opportunity to assess any emergent neurological symptoms and address them promptly