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The 4 allele has been linked to myelin breakdown and accelerated cognitive decline in AD, and myelin abnormalities are also reported in schizophrenia

Mol Med (1995) 1(3):25466

In the present study, we detected significant upregulation of pro-inflammatory factors ( IL1B , TNF , IFNG , NOS2 , CD86 , IL6 and IL12 ) along with downregulation of anti-inflammatory mediators ( IL4 , IL10 , MRC1 and ARG1 ) in the livers of iron-deficient suckling piglets, confirming that ID skews hepatic immunity toward a pro-inflammatory state and causes liver injury

High or low results may indicate an underlying issue, such as iron deficiency anemia, hemochromatosis, or some types of cancer