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Please Note: Nutritional Information is to be used as a guide only, actual values may differ between flavours and sizes and when formulations are modified or updated by the manufacturer

Table 5.4: Common adverse events of the four PDE5Is currently EMA-approved to treat ED* * Adapted from EMA statements on product characteristics

Human medications now account for fewer poisonings in pets than chocolate or household cleaners C

Bakalov 2020), skin rash (NatMed 2025, unclear, unknown grading), hypophosphatemia resolved after discontinuation (NatMed2025)

In cancer cachexia, leptin levels are reduced while ghrelin levels are increased, most probably as a compensatory mechanism, but both are unable to exert their function, suggesting the establishment of a resistance to these hormones (Porporato et al., 2013