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[10], MNA exhibited no passive permeability in parallel artificial membrane permeability assay (PAMPA), which might partly explain the undesirable treatment effects of MNA in the control of body weight and blood glucose homeostasis

Intramuscular replacement therapy is indicated for patients with: Significant B12 deficiency (thresholds depend on local laboratory reference ranges) Neurological symptoms or signs Pernicious anaemia Malabsorption syndromes The standard UK regimen for patients without neurological involvement involves hydroxocobalamin 1mg intramuscularly three times weekly for two weeks, followed by maintenance injections every 2-3 months (often 3-monthly)

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