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In: Cadenas E, Packer L (eds) Handbook of antioxidants

Yokota et al., 2024

4.2 Small molecule inhibitors targeting NNMT In addition to RNAi drugs, the development of small molecule inhibitors targeting NNMT represents a current research focus for the treatment of MetS-related diseases

Alox15 (arachidonate 15-lipoxygenase), Pnpla2 (patatin-like phospholipase domain containing 2), pla2g12a (phospholipaseA2-group XIIA), Gm13033 (prostaglandin-endo-peroxide synthase 2 pseudogene), Ptges (prostaglandin E synthase), and Acot1 (acyl-CoA thioesterase1) are a set of protein-encoded genes which were either upregulated or downregulated within the molecular pathways of DCM (109)