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This protective action of dietary fibers and acetate likely involves downregulation of CVD-associated genes, such as early growth response protein 1 (Egr1)

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Nakamachi T, Matsuda K, Maruyama K, Miura T, Uchiyama M, Funahashi H et al

To answer the first question, we transplanted tumors lacking the ability to produce GSH (Gclc-KO) into wild-type mice and, surprisingly, the tumors grew normally

50% average 5-year survival