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Hafner M, Andersson FL, Burtea T, et al

386 Beyond inhibition of ATP1/2 to inhibit tumor development, inhibition of PPT1 mediated depalmitoylation may lead to more direct toxic effect in cancer cells

L-arginine supplements are generally not recommended for people who have: kidney disease low blood pressure (hypotension) guanidinoacetate methyltransferase deficiency, an inherited condition that impacts arginine metabolism L-arginine may also interact with medications like those used to treat high blood pressure

Its real-world use is doping: the compound is best known for being illegally injected into racehorses as a pain-masking agent, for which it is a classified doping substance with validated forensic detection [6]

Interestingly, it has been shown that double and triple genetic mutations can lead to synergistic lifespan extension benefits by leveraging beneficial interactions between several ageing pathways 13,14