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Discussion Although many antidepressants with different mechanisms are being used, a number of patients have not achieved appropriate therapeutic effects

Phase I metabolism is characterized by functionalization of the drug via one or more of the reactions: Oxidation (electron removal, dehydrogenation, or oxygenation) Reduction (electron addition, hydrogenation, or removal of oxygen) Hydration/dehydration (hydrolysis, and addition or removal of water) These transformations are carried out in the endoplasmic reticulum of hepatocytes and the most prominent Phase I reactions are oxidations

For this reason, make sure to avoid vitamin B12-fortified foods that are sold or stored in clear containers or plastic bags (10)

Smith EA, Macfarlane GT

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