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Description

According to the protein misfolding avoidance hypothesis, natural selection disfavors the misfolding of highly expressed proteins, thereby constraining their evolution to minimize cytotoxicity 38

Volume 466

The rationale stems from evidence that specific micronutrients and bioactive compounds influence biological processes central to BD pathophysiology, including neuroinflammation, oxidative stress, mitochondrial function, and neurotransmitter regulation [11,12]