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Sleep deprivation and disturbances significantly affect inflammation, immunity, neurodegeneration, cognitive depletion, memory impairment, neuroplasticity, and insulin resistance

[PUBMED Abstract] Bhatia S, Landier W, Shangguan M, et al.: Nonadherence to oral mercaptopurine and risk of relapse in Hispanic and non-Hispanic white children with acute lymphoblastic leukemia: a report from the children's oncology group

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in AD, this enzymatic cascade is upregulated and switched to the urea cycle mode, resulting in both helpful and harmful outcomes 545 (Fig