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[2] An important caveat applies to all of this work: these studies measure DSIP-like immunoreactivity (DSIP-LI) using antisera, which detects material that cross-reacts with the antibody

A scientific review published in the National Library of Medicine in 2022 found that nose-to-brain delivery of therapeutic peptides is a non-invasive and fast-acting method that can effectively bypass the blood-brain barrier while minimizing systemic exposure