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They also act as redox regulators by controlling reactive oxygen species (ROS), as calcium buffers by limiting cytosolic Ca 2+ overload, as signaling platforms that influence pathways such as NF-B, HIF-1, and mTOR, and as key mediators of cellular fate through activation of the intrinsic apoptotic pathway (Yan et al., 2026) (see Figure 1)

Leukemia 17:931940 Dejeans N, Glorieux C, Guenin S, Beck R, Sid B, Rousseau R, Bisig B, Delvenne P, Buc Calderon P, Verrax J (2012) Overexpression of GRP94 in breast cancer cells resistant to oxidative stress promotes high levels of cancer cell proliferation and migration: implications for tumor recurrence

Pharmacological intervention Experimental groups were established, each comprising 6 model mice and 6 control mice

Examination of Org 26576, an AMPA receptor positive allosteric modulator, in patients diagnosed with major depressive disorder: an exploratory, randomized, double-blind, placebo-controlled trial

Cannabis, in particular, is one of the oldest recreational substances with a long history of use, while MDMA has been extensively studied for its recreational effects since its emergence several decades ago