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Yet chronic HIF activation, as observed in prolonged anemia or systemic hypoxia, contributes to inflammatory signaling, tissue remodeling, and mitochondrial dysfunction, accelerating cellular senescence and organ aging [39]

291 Moreover, NOX-induced ROS play various roles in the mechanisms of oncogenesis by HCV, including genome instability, epigenetic regulation, inflammation and modulation of cell growth and death

Methods In this study, we design a two-in-one ferroptosis-inducing nanoplatform using iron-based metal-organic framework (MOF) that combines iron supply and GPX4 deactivation by loading the small molecule buthionine sulfoxide amine (BSO) to block de novo GSH biosynthesis, which can achieve sustainable GSH elimination and dual ferroptosis amplification

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F., Joffe, M